Adenophostins A and B: Potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Structure elucidation.
نویسندگان
چکیده
منابع مشابه
Copper uptake by Penicillium brevicompactum.
The copper binding properties of Penicillium brevicompactum biomass were influenced by growth phase of mycelium and concentration of copper in reaction mixtures. The efficiency of copper uptake increased with growth time and was largest at the mid-logarithmic growth phase. The time course of copper uptake was biphasic. Double reciprocal plots of absorption velocity of copper vs. copper concentr...
متن کاملStructure and function of inositol 1,4,5-trisphosphate receptor.
Generation of intracellular Ca2+ signals in response to Ca(2+)-mobilizing stimuli is a critical event in the control of many cellular processes. Inositol 1,4,5-trisphosphate (IP3) represents a dominant second messenger subserving the release of Ca2+ from intracellular store sites. The protein on the surface of which the IP3 receptor is located comprises an IP3-gated Ca2+ channel, and binding of...
متن کاملStructure and expression of the rat inositol 1,4,5-trisphosphate receptor.
The complete primary structure of the inositol 1,4,5-trisphosphate receptor from rat brain was elucidated using a series of overlapping cDNA clones. Two different sets of clones that either contain or lack a 45-nucleotide sequence in the amino-terminal third of the protein were isolated, suggesting a differential splicing event that results in the biosynthesis of either a 2734- or 2749-amino ac...
متن کاملStructural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptors.
Adenophostins A and B, which are metabolic products of the fungus Penicillium brevicompactum, are potent agonists at the D-myo-inositol-1,4,5-trisphosphate [Ins(1,4,5)P3] receptor. In the current study, adenophostin A was approximately 50-fold more potent than Ins(1,4,5)P3 at both releasing Ca2+ from the intracellular stores of permeabilized platelets and displacing [3H]Ins(1,4,5)P3 from its re...
متن کاملIsolation, Structure elucidation and Biological Activity of Di- (2-ethylhexyl) phthalate Produced by Penicillium janthinellum 62
On the course of screening program for new bioactive compounds, the present study was carried out on the crude extract of Penicillium janthinellum 62. The crude extract of P. janthinellum 62 was fractionated on silica gel column and Sephadex-LH20, ten active fractions were produced. Fraction 7 showed highest antitumor activity, which then purified using preparative TLC and produced six sub-frac...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1994
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.47.95